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Dose Form Description: powder
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The pharmacogenetics of paclitaxel and gemcitabine

Author: Anna Kim Fukunaga

Manufacturer: ProQuest / UMI

Keywords: gemcitabine

Rubric: Medical surgical books

ISBN: 0542276399

Book description

Paclitaxel binds to beta tubulin, causing stabilization of polymerized microtubules resulting in cell cycle arrest and the inhibition of mitosis. Recently, low-dose paclitaxel has demonstrated anti-angiogenic activity. A phase I trial was designed to assess the safety of escalating paclitaxel in combination with alpha interferon. Pharmacokinetic parameters of paclitaxel alone and in combination with interferon are determined using ADAPT software. Paclitaxel exhibits variable pharmacokinetics and toxicity. Polymorphisms in the paclitaxel pharmacologic pathway may help explain this interindividual variability. Seventeen subjects in this phase I trial were genotyped using PCR and pyrosequencing…

Medical surgical books: Tarascon Adult Emergency Pocketbook, Third Edition, Diabetes in France: The Markets for Monitoring, Insulin, Oral Hypoglycemics, and Drugs to Treat Complications, Muscles: Testing and Function, with Posture and Pain

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