Generic aminohippurate information

Generic Drug: aminohippurate

Brand Name: Aminohippurate Sodium

Active Ingredient: aminohippurate sodium
Dose Form Description: solution
Route Description: intravenous
Aminohippurate Strength Description: 20%

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Hypoxia: Induction of stress-caused resistance to the topoisomerase II inhibitor etoposide in human cancer cells

Author: Irini S. Hadjisavva

Manufacturer: ProQuest / UMI

Keywords: Etoposide

Rubric: Nursing drug reference books

ISBN: 0496911708

Book description

Conditions within solid tumor microenvironments can activate stress response pathways leading to the development of resistance to anti-cancer drugs. To elucidate pathways by which stress-induced drug resistance occurs, human cell lines under normoxic and hypoxic conditions were evaluated. Exposure to hypoxia or Brefeldin A (BFA) led to the development of resistance to the topoisomerase II inhibitor etoposide in MDA-MB-231 and MCF-7 human breast cancer cells, PC-3 human prostate cancer cells and H1299 (p53-/-) human lung cancer cells. Experiments using an NF-κB-regulated luciferase reporter construct demonstrated that hypoxia or BFA induce NF-κB activation in MCF-7, PC-3 and H1299…

Nursing drug reference books: PocketRadiologist - Gynecologic: Top 100 Diagnoses, Labor of Love: Mothers Share the Joy of Childbirth, Statistical Methods for Health Care Research

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