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Read book description Discovering the molecular and cellular mechanisms underlying fenfluramine-induced cardiopulmonary side
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Discovering the molecular and cellular mechanisms underlying fenfluramine-induced cardiopulmonary side effects
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Discovering the molecular and cellular mechanisms underlying fenfluramine-induced cardiopulmonary side effects


Author: Vincent Setola
Manufacturer: ProQuest / UMI
Keywords: fenfluramine
ISBN: 054206362X

Book description
G protein-coupled receptors (GPCRs) are plasma membrane proteins that act as sensors for extracellular stimuli (e.g., photons, neurohumoral moduluators, odorants and tastants, lipids). The cognate stimulus for a GPCR induces a conformational change that catalyzes, via heterotrimeric G proteins, a series of biochemical reactions inside the cell (i.e., a response); the responses can lead to phenomena such as differentiation, morphological changes, chemotaxis, and mitosis. G protein-coupled receptors are the targets of, in addition to endogenous neurohumoral molecules, more than 30% of currently marketed pharmaceutical drugs. For instance, the effective appetite suppressant fenfluramine reduces…


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