Abstract During menopause, women often experience vasomotor symptoms and other sequelae due to low levels of estrogens. Hormone replacement therapy (HRT) is used by many women for the management of menopausal symptoms. However, long-term estrogen replacement therapy is associated with an increased risk of developing breast and
endometrial cancers and other side effects.
Botanical dietary supplements are being used by some women as potential alternatives to HRT, but these products are in need of careful standardization and evaluation for safety and efficacy. Therefore,
mass spectrometry based assays were developed to screen and evaluate botanical dietary supplements for estrogen content. As a