Cancer has been afflicting populations worldwide throughout recorded history. Despite making
significant progress in-the treatment of cancer, the prognosis for most
cancer types remains grim. Thus, novel approaches for treating this disease are still needed. Pharmacogenomics, a branch of pharmacology particularly relevant to the cancer research field, is the study of how variations in the
genome affect response to pharmaceutical agents and influence biological pathways and processes, including the pharmacokinetics, pharmacodynamics, efficacy, and toxicity of a drug. The observations detailed in this dissertation suggest that, by utilizing a pharmacogenomic approach, it is possible to design…
