For clinical chemistry and biomedical applications, reference materials (RMs) or certified reference materials (CRMs) may take the form of neat materials of assessed purity, or solutions of analytes. A Standard Reference Material® (SRM) is a CRM issued by the United States National Institute of Standards and Technology (NIST). As SRMs are precious commodities, they typically are not intended for routine clinical or
experimental applications as controls. Intended use descriptions often accompany supporting documentation of such standards. As part of continued NIST
commitment to healthcare, recent NIST workshops have addressed standards and technology in areas such as nanotechnology and early