Authors: M. Blanco, M. Alcala
Manufacturer: Copyright (c) 2006 Elsevier B.V.
The use of process analytical technologies by the pharmaceutical industry is a response to its growing need for improved productivity in order to face the increasing competition in this field. In this work, we explored the use of near infrared
spectroscopy (NIRS) for the determination of physical (tablet hardness) and chemical parameters (active principle and content
uniformity) in intact individual pharmaceutical tablets. Quantization was done by using a Partial Least Squares 1 (PLS1) calibration model constructed
from laboratory calibration samples that were prepared by mixing the active principle and excipients, and pressing the mixture into tablets. The compaction pressure to be applied…
