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Generic Drug: chloramphenicol otic
Brand Name: Chloromycetin Otic

Active Ingredient: chloramphenicol
Dose Form Description: solution
Route Description: otic
Chloramphenicol otic Strength Description: 0.5%

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Evaluation of gastrointestinal absorption of digoxin
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Evaluation of gastrointestinal absorption of digoxin


Author: Hsuan-Ming Yao
Manufacturer: ProQuest / UMI
Keywords: Digoxin
ISBN: 0542250500

Book description
Digoxin is a widely used, poorly water-soluble cardiac glycoside with a narrow therapeutic index. There is a substantial variation in absolute bioavailability. However, the precise mechanism responsible for the variability has not been fully elucidated. Because of its lipophilicity and apparent linear absorption over a wide concentration range from the same dosage form, digoxin has long been assumed to be absorbed across apical membrane of enterocytes by passive diffusion. Studies using the rat intestinal BBMV and in vitro Ussing chamber methods suggest the involvement of multiple transport mechanisms (both uptake and efflux transporters) for digoxin absorption. The influence of two…


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