Authors: S. Croubels, S. De Baere, P. De Backer
Manufacturer: Copyright (c) 2006 Elsevier B.V.
According to the SANCO/1805/2000 document and the EMEA/CVMP/573/00 guideline, one of the performance characteristics to be determined for an analytical method is the analyte stability. A practical approach is presented for the stability testing of veterinary drugs in
solvents and in
biological matrices during storage. These drugs comprise analytes belonging to the classes of antibiotics, sulfonamide
chemotherapeutics, anthelminthics and non-steroidal anti-inflammatory drugs. Examples of the stability in solution are given for clindamycin, ketoprofen, oxytetracycline, 4-epioxytetracycline, sulfadiazine, trimethoprim, tylosin A and their respective internal standards. For the stability in