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Generic Drug: conjugated estrogens-methylTESTOSTERone
Brand Name: Premarin with Methyltestosterone

Active Ingredients: conjugated estrogens; methyltestosterone
Dose Form Description: tablet
Route Description: oral
Conjugated estrogens-methylTESTOSTERone Strength Descriptions: 0.625 mg-5 mg; 1.25 mg-10 mg

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Celecoxib: Its non-COX-2 targets and its anti-cancer effects
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Celecoxib: Its non-COX-2 targets and its anti-cancer effects


Author: Ho-Pi Lin
Manufacturer: ProQuest / UMI
Keywords: celecoxib
ISBN: 0542242508

Book description
Our previous work showed that celecoxib (Celebrex®), a nonsteroidal anti-inflammatory drug (NSAID, cyclooxygenase-2 inhibitor) was unique among other cyclooxygenase-2 (COX-2) inhibitors in its superior ability to induce prostate cancer cell death, indicating the involvement of non-COX-2 components in the mode of action of celecoxib. To test this hypothesis, we investigated the effect of COX-2 depletion on apoptosis by tetracycline controllable COX-2 antisense constructs and performed a structure-activity analysis of the COX-2 inhibitor celecoxib in PC-3 cells. Both strategies came out with the same conclusion, which is the unique apoptotic inducing activity of celecoxib comes from…


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