The malfunction and dying back of peripheral nerves induced by peripheral inflammation and neuropathy is a common factor that limits therapy with
chemotherapeutic drugs. Little is known about the mechanisms responsible for these processes. The complexity of type I slowly adapting mechanoreceptor structure and its chemosensitivity suggest its fragility in terms of chemically-induced neuropathy. The goal of this dissertation research was to study peripheral inflammation and neuropathic injury induced by
chemotherapy agents and their effects on the type I mechanoreceptor in order to gain further understanding of this clinically important form of dying-back
peripheral neuropathy. The research…
