Authors: M.R. Zarrindast, M. Bananej, A. Khalilzadeh, S. Fazli-Tabaei, A. Haeri-Rohani, A. Rezayof
Manufacturer: Copyright (c) 2006 Elsevier Inc.
The effects of dopaminergic drugs on morphine state-dependent memory of passive
avoidance task were examined in mice. Pre-training administration of morphine (5mg/kg) led to state-dependent learning with impaired memory retrieval on the test day which was reversed by pre-test administration of the same dose of the opiate. The pre-test
intracerebroventricular (i.c.v.) administration of the dopamine D"1 receptor agonist (SKF38393), dopamine D2 receptor agonist (quinpirole) and dopamine D2 receptor
antagonist (sulpiride) not only reversed the effect of pre-training morphine treatment, but also increased this action of the drug. Furthermore, the pre-test i.c.v. administration of dopamine D"1…
