Authors: M. Suwalsky, S. Mennickent, B. Norris, H. Cardenas
Manufacturer: Copyright (c) 2006 Elsevier Inc.
The effects of phenytoin on isolated Pleurodema thaul toad skin were investigated. Low (micromolar) concentrations of the antiepileptic agent applied to the outside surface of the toad
epithelium increased the electrical
parameters (short-circuit current and potential difference) by over 40%, reflecting
stimulation of Na^+ transport, whereas higher (millimolar concentrations, outside and inside surface) decreased both electric parameters, the effect being greater at the inside surface (40% and 80% decrease, respectively). The amiloride test showed that the stimulatory effect was accompanied by an increase and the inhibitory effect by a decrease in the sodium electromotive force (ENa). It is…
