Building on the excellent foundations laid down by earlier editions, this third edition of a popular textbook thoroughly introduces the principles of rational drug design. Adopting a 'from the bench to the market place' approach and explaining the principles of drug design using real examples, the book illustrates the discovery of lead compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a
predicted fashion. New sections cover the pharmacological consequences of drug chirality, agonists and
antagonists of
neurotransmitters, and the process involved in proceeding from program sanction to clinical…
