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Brand Name: Emtriva

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Dose Form Descriptions: capsule; solution
Route Description: oral
Emtricitabine Strength Descriptions: 10 mg/mL; 200 mg

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Novel cyclophosphamide prodrugs for site-specific activation in tumor cells

Author: Yongying Jiang

Manufacturer: ProQuest / UMI

Keywords: Cyclophosphamide

Rubric: Pharmacy technician books

ISBN: 0542156245

Book description

Cyclophosphamide is an alkylating agent that is effective against a variety of human cancers, including advanced prostate cancer. Due to its limited selectivity against tumor cells, cyclophosphamide is associated with serious systemic side effects. In order to develop anticancer agents with high tumor-specificity, two novel series of cyclophosphamide prodrugs were designed, synthesized and evaluated incorporating tumor-specific activation mechanisms. The first series, 4-nitrophenylcyclophosphamides, were designed to be activated by E. coli nitroreducase (NTR), an enzyme that has been used in antibody-directed and gene-directed enzyme prodrug therapy (ADEPT and GDEPT). Among the analogs…

Pharmacy technician books: Comprehensive Gynecology Package, Saunders Drug Handbook for Health Professions (Saunders Drug Handbook for Health Professionals), Happy, Healthy Moms and Babies: Breastfeeding Basics: A Lactation Consultants Advice for Breastfeeding during Your Hospital Stay

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