Antisense drug treatments function by targeting a particular genetic sequence that is responsible for genetic disorders or infections and "
inactivating" it. While initial
synthetic nucleic acids were less than successful, numerous second-generation antisense drugs have shown excellent results in clinical trials. Addressing the core principles and benefits of RNA-based drugs, Antisense Drug Technologies, Second Edition provides an integrated overview of the status, recent progress, and
future prospects for RNA-based therapeutics. Topics in this new edition include newly discovered mechanisms of action, mechanisms of distribution, pharmacokinetics, and mechanisms of toxicology.
