Generic ethanolamine oleate information

Generic Drug: ethanolamine oleate

Brand Name: Ethamolin

Active Ingredient: ethanolamine oleate
Dose Form Description: solution
Route Description: injectable
Ethanolamine oleate Strength Description: 50 mg/mL

What is ethanolamine oleate?
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From celebrex to a novel class of phosphoinositide-dependent kinase 1 (PDK-1) inhibitors for androgen-independent prostate cancer: (Dissertation)

Author: Jiuxiang Zhu

Manufacturer: ProQuest Dissertations

Keywords: Celebrex

Rubric: Best drug books

ISBN: B000AR8QCW

Book description

Abstract Celebrex, a nonsteroidal anti-inflammatory drug (NSAID, cyclooxygenase-2 inhibitor), was reported to induce apoptosis in the prostate cancer cell line PC-3 at 50μM. Early research from our laboratory demonstrated that this apoptotic inducing effect was independent of its COX-2 inhibitory activity. Further investigation showed that PDK-I was a major protein targeted by celebrex in PC-3 cells to induce apoptosis. However, celebrex was very weak in inhibiting PDK-1 with IC50 of 48μM. To improve its potency, two series of analogs were designed and synthesized. In the first series of 24 compounds, the 5-position methylphenyl moiety of celebrex was replaced by various aromatic ring…

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