Authors: Joachim K. Seydel, Michael Wiese
Barrier, reservoir, target site - those are but some of the possible functions of biological lipid
membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with
biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including
computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples…
