Author: James J. Crowley
Abstract Pharmacogenomics is a developing area of biomedical research that aims to identify
genetic variants capable of
predicting an individual's response to drug treatment. The identification of genes regulating antidepressant response will allow for more individualized, rational and successful drug treatments. This thesis has identified the BALB/cJ inbred mouse strain as highly responsive to the selective serotonin reuptake inhibitor (SSRI)
citalopram in the tail suspension test (TST), a widely used and well-established screening paradigm for detecting compounds with antidepressant activity. In contrast, A/J mice did not show a significant response to citalopram in this test. To identify…
