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Read book description Mechanisms of TNF-alpha receptors-mediated cytoprotective signaling against adriamycin-induced
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Mechanisms of TNF-alpha receptors-mediated cytoprotective signaling against adriamycin-induced cardiotoxicity: (Dissertation)
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Mechanisms of TNF-alpha receptors-mediated cytoprotective signaling against adriamycin-induced cardiotoxicity: (Dissertation)


Author: Yu-Chin Lien
Manufacturer: ProQuest Information and Learning
Keywords: Adriamycin
ISBN: B000GQM3Y4

Book description
AbstractAdriamycin (ADR) is a widely used chemotherapeutic agent. However, dose-related cardiomyopathy that may lead to congestive heart failure is a major limiting factor for the clinical application of ADR. The most prevailing hypothesis for ADR-induced cardiac injury is the increases of oxidative stress. The previous study in our laboratory has demonstrated that overexpression of MnSOD in the transgenic mice protected against ADR-induced acute cardiac injury. Tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine produced also by cardiomyocytes, is a well-known MnSOD inducing factor with both adaptive and maladaptive effects on cardiac function. In the present study, we…


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