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Brain-derived tumor necrosis factor-alpha (TNF) mediates the antinociceptive effect of amitriptyline and modulates brain-body interactions during neuropathic pain

Author: Reeteka Sud

Manufacturer: ProQuest / UMI

Keywords: amitriptyline

Rubric: Veterinary medical books

ISBN: 0542058057

Book description

The present study was designed to investigate the involvement of the cytokine tumor necrosis factor-α (TNF) in the brain in the antinociceptive mechanism of action of the antidepressant drug amitriptyline. Amitriptyline is one of the most commonly employed antidepressants in the clinical management of chronic neuropathic pain, however the mechanism of its action remains unknown. Previous studies from our laboratory have demonstrated a central role of elevations in brain-derived TNF levels in the pathogenesis of neuropathic pain. As an extension of these findings, in the present study, the involvement of this cytokine in the antinociceptive mechanism of amitriptyline was investigated.

Veterinary medical books: Nitrofuran antibiotic residues in pork, Medical Microbiology: with STUDENT CONSULT Access (Medical Microbiology), Saunders Electronic Nursing Drug Cards 2002 (with PC compatible mini-CD-ROM)

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