Author: Christal G. Coleman
The recent derivation of the mouse genome has made the mouse the most important animal model
in biomedical research. Little is known about the
neuropharmacology of arousal state control in mouse. The three studies that comprise this thesis sought to elucidate the pontine muscarinic and adenosine receptor mechanisms contributing to the rapid eye movement (REM) phase of sleep in C57BL/6J (B6) mouse. The first study used drug delivery by microinjection to test the hypothesis that M2 muscarinic receptors in the pontine reticular formation (PRF) of B6 mouse contribute to the REM sleep-like state caused by PRF administration of the
acetylcholinesterase inhibitor neostigmine. The…
