This Ph.D. thesis aims to contribute to the development, validation and practical application of breath tests for measuring
gastric emptying and orocaecal transit time in infants and children. The study of healthy subjects and patients has lead to a better understanding of the
gastrointestinal physiology. The established reference values will serve to diagnose
motility disturbances in the pediatric age group and design more adequate therapeutic modalities. Contents include: Introduction. The [13C]octanoic acid breath test: background. Maturation of gastric emptying in healthy infants and children and reference values for the [13C]octanoic acid breath test. An alternative breath test for