Author: Scott C. Wasdo
Topical delivery is an attractive route of administration for a number of
therapeutic agents. However, many drugs possess physical and chemical properties that limit their ability to permeate the skin. By masking select functional groups on a drug with proper moieties, it is possible to create prodrugs with physical and chemical properties that greatly improve topical delivery. Efficient development of these prodrugs requires knowledge of how the physical and chemical characteristics of a drug influence
dermal absorption. In response to this need, solubility and diffusion experiments were performed on prodrugs of 5-flurouracil,
6-mercaptopurine and theophylline to develop a model that…
