Bortezomib modulates TRAIL sensitivity in human bladder and prostate cancer: (Dissertation)
Author: Laura Michelle Lashinger Manufacturer: ProQuest Information and Learning Keywords: bortezomib ISBN: B000FIGAU6
Book description Abstract Tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is a member of the TNF superfamily of cytokines that can induce cell death through engagement of cognate death receptors. Unlike other death receptor ligands, it selectively kills tumor cells while sparing normal cells. Preclinical studies in non-human primates have generated much enthusiasm regarding its therapeutic potential. However, many human cancer cell lines exhibit significant resistance to TRAIL-induced apoptosis, and the molecular mechanisms underling this are controversial. Possible explanations are typically cell-type dependent, but include alterations of receptor expression, enhancement of… Veterinary medical books: Advances in Breast Cancer Management, AIDS and Intravenous Drug Use: The Influence of Morality, Politics, Social Science, and Race in the Making of a Tragedy, Nutrition: Concepts and Controversies, MyPyramid Update (with Nutrition Connections CD-ROM and InfoTrac®), A Systematic Treatise Historical, Etiological and Practical on the Principal Diseases of the Interior Valley of North America: 1850, Medical Immunology: Text and Review |
