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Read book description Induction of endoplasmic reticular stress by bortezomib: A novel therapeutic strategy for pancreatic
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Induction of endoplasmic reticular stress by bortezomib: A novel therapeutic strategy for pancreatic cancer
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Induction of endoplasmic reticular stress by bortezomib: A novel therapeutic strategy for pancreatic cancer


Author: Steffan Todd Nawrocki
Manufacturer: ProQuest / UMI
Keywords: bortezomib
ISBN: 0542042169

Book description
Bortezomib (VELCADE™, formerly known as PS-341) is a selective and potent inhibitor of the proteasome that was recently FDA-approved for the treatment of multiple myeloma. Despite its success in multiple myeloma and progression into clinical trials for other malignancies, bortezomib's exact mechanism of action remains undefined. The major objective of this study was to evaluate the anticancer activity of this drug using in vitro and in vivo pancreatic cancer models and determine whether bortezomib-induced apoptosis occurs via induction of endoplasmic reticular (ER) stress. The investigation revealed that bortezomib inhibited tumor cell proliferation via abrogation of cdk activity and…


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