Since the discovery some 15 years ago of benzodiazepine modulatory sites associated with GABA A receptors, great effort has gone into understanding their
molecular pharmacology and into developing new
anxiolytic drugs that interact
selectively with them. Prominent in this research has been the discovery that ß-carbolines, a different chemical class from benzodiazepines, also act at these receptors but that their effects are sometimes quite different from those of the benzodiazepines.This book documents the latest discoveries in the molecular biology of the GABA A receptor and reveals how an integration of the results of research in molecular biology, synthetic chemistry, biochemical and…
