Over the last decade, the advent of biologic agents has greatly revolutionized
therapeutic medicine in the management of chronic inflammatory diseases, such as rheumatoid arthritis, Crohn's disease, and psoriasis. Elucidation of the complex web of cytokine network and the roles of these cytokines in the pathogenesis of
inflammatory disorders provided one of the key catalysts for the advancement of
targeted biologic therapy in autoimmune and inflammatory diseases. TNF-alpha is known to play a crucial role in the pathogenesis of many chronic inflammatory diseases. Elevated levels of TNF-alpha have been demonstrated in Crohn's disease, psoriasis, psoriatic arthritis, and rheumatoid arthritis…
