Bacterial pathogenesis is highly dependent on the ability of organisms to colonize host tissues.
Staphylococcus aureus ( S. aureus) is generally considered an extracellular pathogen compared to other facultative intracellular organisms such as Listeria, Salmonella, and Mycobacteria. However, adherence to endothelial cells (EC) by S. aureus can lead to internalization of the bacteria by the EC. The consequence of bacterial internalization is not exactly known. The survival and replication of S. aureus within endothelial cells (where they are protected from host defenses and antibiotics) plays an important role in the frequency and persistence of invasive
staphylococcal infections. Bovine…
