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Read book description Optimization of intraperitoneal topotecan chemotherapy with anti-topotecan antibodies: (Dissertation)
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Brand Name: Sulfamethoxazole-Trimethoprim DS
Generic Drug: Sulfamethoxazole-Trimethoprim

Active Ingredients: sulfamethoxazole; trimethoprim
Dose Form Description: tablet
Route Description: oral
Sulfamethoxazole-Trimethoprim DS Strength Description: 800 mg-160 mg

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Optimization of intraperitoneal topotecan chemotherapy with anti-topotecan antibodies: (Dissertation)
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Optimization of intraperitoneal topotecan chemotherapy with anti-topotecan antibodies: (Dissertation)


Author: Jin Chen
Manufacturer: ProQuest Information and Learning
Keywords: topotecan
ISBN: B000EQGX9C

Book description
Abstract This dissertation presents an approach to optimize topotecan (TPT) intraperitoneal chemotherapy using anti-topotecan antibodies (ATAb). We hypothesize that ATAb may be used to decrease systemic unbound TPT exposure (AUCf), decrease TPT-induced systemic toxicity and enhance the efficacy of TPT intraperitoneal chemotherapy. The limitations of 'traditional' targeting strategies, as well as different 'inverse targeting strategies' to improve the regio-selectivity of drug disposition were reviewed. A sensitive HPLC assay was developed to quantify total and unbound TPT plasma concentrations in mice, with or without the presence of anti-TPT antibodies. The assay has a working range of…

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