Abstract Troglitazone (TG) holds a unique apoptosis-inducing ability, which is not found in other synthetic
peroxisome proliferator-activated receptor γ (PPARγ) ligands like rosiglitazone or pioglitazone, and we have reported that the inhibition of Bcl-2/Bcl-xL functions is a major PPARγ independent mechanism for apoptosis-inducing effect of troglitazone. In this study, we start from exploring an
interesting drugs
interaction between TG and celecoxib. Our data indicates 10 μM celecoxib can sensitize TG-induced apoptosis in PC-3 cells and HT-29 cells. This effect is not related to either cyclooxygenase-2 (Cox-2) activity of celecoxib or PPARγ activity of TG. In