Molecular mechanisms underlying the multiple neuroprotective activities of a novel anti-Alzheimer's dimer bis(7)-tacrine: (Dissertation)
Author: Wenming Li Manufacturer: ProQuest Information and Learning Keywords: tacrine ISBN: B000FIGBR8
Book description Abstract Neurodegenerative diseases are among the leading causes of death, disability, and economic expense in the world. Most of their mechanisms are unclear and no effective therapeutics is available yet. However, these diseases may share a final common pathway of neuronal injury due to the excitotoxicity caused by the overstimulation of N-methyl-D-aspartate (NMDA) receptor/nitric oxide (NO) pathway. Therefore, neuroprotection afforded by interfering with the NMDA receptor and its downstream signaling molecules may be beneficial to these diseases. Bis(7)-tacrine, a novel dimeric acetylcholinesterase (AChE) inhibitor, possesses high potency and selectivity to AChE and potential
|