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Read book description Pharmacokinetics of zidovudine and stavudine in the cerebrospinal fluid during intrathecal
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Generic Thiopental Sodium information



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generic thiopental sodium information

Brand Name: Thiopental Sodium
Generic Drug: thiopental

Active Ingredient: thiopental sodium
Dose Form Description: powder for injection
Route Description: intravenous
Thiopental Sodium Strength Descriptions: 1 g; 2.5 g; 5 g; 500 mg

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Pharmacokinetics of zidovudine and stavudine in the cerebrospinal fluid during intrathecal administration in a novel rabbit model
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Pharmacokinetics of zidovudine and stavudine in the cerebrospinal fluid during intrathecal administration in a novel rabbit model


Author: Yan Song
Manufacturer: ProQuest / UMI
Keywords: stavudine
ISBN: 0542310627

Book description
This thesis reports the pharmacokinetics of zidovudine (AZT) and stavudine (d4T) in the cerebrospinal fluid (CSF) in a novel rabbit model following intrathecal administration. The involvement of active transporters in the disposition of these two drugs was also investigated. In this research, thirty-two New Zealand White rabbits were used and surgically prepared prior to drug administration In the infusion studies, AZT or d4T was given either as an 8-hr intrathecal infusion alone (5 μg/min) or co-infusion (2.5 μg/min) with an organic anion transporter inhibitor, probenecid (PBD) (0.5 μg/min). In the bolus studies, AZT or d4T was given as a single intrathecal dose (500 μg). Free…


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