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Read book description Enhancing rituximab therapy: Analyzing the interaction between rituximab and the human complement
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Generic Topamax Sprinkle information



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generic topamax sprinkle information

Brand Name: Topamax Sprinkle
Generic Drug: topiramate

Active Ingredient: topiramate
Dose Form Description: capsule
Route Description: oral
Topamax Sprinkle Strength Descriptions: 15 mg; 25 mg

Which pharmaceuticals companies are producing Topamax Sprinkle?
Janssen Pharmaceuticals

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Medication Guide & Drug Finder Health.msn.com
General rubric: Pharmaceutical guide

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Generic Tomycine information
Generic Tolnate information
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Enhancing rituximab therapy: Analyzing the interaction between rituximab and the human complement pathway: (Dissertation)
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Enhancing rituximab therapy: Analyzing the interaction between rituximab and the human complement pathway: (Dissertation)


Author: Adam David Kennedy
Manufacturer: ProQuest Information and Learning
Keywords: rituximab
ISBN: B000F7NQ1S

Book description
Abstract Rituximab (RTX) is a chimeric monoclonal antibody (mAb) used for treatment of B cell lymphomas as well as for several autoimmune diseases. In vitro, RTX opsonization of CD20+ cells in the presence of serum promotes covalent deposition of large amounts of C3b(i) (C3 activation fragments) ultimately leading to cell lysis by the membrane attack complex. RTX-mediated C3b(i) deposition and cell killing are enhanced with the anti-C3b mAb 3E7; this enhancement does not occur with other anti-C3b(i) mAbs and killing is directed at B cells. Fluorescence microscopy experiments suggest that C3b(i) is co-localized with bound RTX on B cells. However, <12% of deposited C3b(i) co-precipitates with…


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