In organs such as the kidney and the intestines, the Na+, K +-ATPase regulates fluid reabsorption and electrolyte movement by establishing an ionic gradient across the epithelial membranes (1, 2).
Prostaglandins are biologically potent lipid acids which play significant roles in the regulation of
membrane transport within the kidney (1, 3). Of the two Na+, K +-ATPase subunits, the β-subunit is essential for the functional expression of the pump (4). Hence, the β-subunit has been observed to be a limiting factor in the Na+, K+-ATPase heterodimer formation (3-5). Taub et al. (3) showed that the β1 mRNA levels were higher than the α1 mRNA following treatment with…
