Author: Scott R. Croy
AbstractThis dissertation covered formulation of the antifungal drug nystatin by nonionic surfactant micelles. Nystatin is an amphiphilic and amphoteric molecule that aggregates in aqueous media. Unimers of nystatin show strong selectivity for fungal
cell membranes, where they exert their activity. However, aggregates are not selective and are able to cause damage to fungal and mammalian
cell membranes. It was proposed that nonionic surfactant micelles could prevent or reduce the aggregation, and therefore the toxicity, of nystatin by improvement in its solubilization at the micellar core.
Surfactants studied included the class known as poloxamers, as well as CrEL and polysorbate 80. These…
