The regimens of
present day chemotherapy utilize drugs that are toxic to both the tumor and normal tissue. As a result, many patients suffer from the side effects of chemotherapy without reaping the benefits. At present, there is no effective strategy to solve this problem. Thus, there is a necessity to develop a more specific and less toxic
cancer therapy. The work presented in this research project reflects a novel approach towards the enhancement of paclitaxel efficacy in breast tumor by selectively increasing tumor blood flow by Endothelin B (ETB) receptor mediated
vasodilatation. The hypothesis tested in this project was that stimulation of ET B receptor agonists in tumor can…
