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Read book description Investigation of hepatic and intestinal mycophenolic acid glucuronidation in relation to
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Generic Tylenol Sinus Day/Night Convenience Pack information



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Brand Name: Tylenol Sinus Day/Night Convenience Pack
Generic Drug: APAP/ doxylamine/ pseudoephedrine

Active Ingredients: acetaminophen; doxylamine succinate; pseudoephedrine hydrochloride
Dose Form Description: kit
Route Description: oral
Tylenol Sinus Day/Night Convenience Pack Strength Description: varying strength

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Johnson and Johnson/Merck Consumer

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Investigation of hepatic and intestinal mycophenolic acid glucuronidation in relation to gastrointestinal toxicity in rat: (Dissertation)
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Investigation of hepatic and intestinal mycophenolic acid glucuronidation in relation to gastrointestinal toxicity in rat: (Dissertation)


Author: Kristini Kume Miles
Manufacturer: ProQuest Information and Learning
Keywords: mycophenolic acid
ISBN: B000GKZBDA

Book description
Abstract Mycophenolic acid (MPA), an immunosuppressant used in anti-rejection therapy, is detoxified by UDP-glucuronosyltransferases (UGTs). Unfortunately, gastrointestinal (GI) toxicity is frequently associated with MPA. Overall objectives were to characterize MPA glucuronidation in rat and to determine if intestinal MPA UGTs mediate a protective role against MPA-induced GI toxicity. Liver microsomel MPA glucuronidation was evaluated for rats and humans. Rat liver microsomes (RLM) demonstrated a lower affinity and activity towards MPA as compared to human liver microsomes (HLM). Hepatic MPA glucuronidation was shown to be primarily mediated by UGT1A1, 1A6 and 1A7 in rats. Kinetic analysis…


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