Authors: N.C. Newby, P.C. Mendonca, K. Gamperl, E.D. Stevens
We made a single intraperitoneal (IP)
injection of morphine sulfate (40mg/kg) into winter flounder and seawater acclimated rainbow trout at 10^oC and then followed its disposition by measuring the change in plasma morphine
concentration for 100h using a morphine specific ELISA. Disposition also was followed for 6h after a single IV injection of 7.5mg morphine sulfate in winter flounder. Plasma morphine reached a maximum within an hour post-injection IP and then decreased in a bi-exponential fashion with a rapid distribution phase followed by a slower elimination phase. The disposition was slower in flounder than in trout even though the fish were held at the same
temperature. For example