Purpose. The objective of this project was to develop an intravenously administrable poly(dl-lactic-co-glycolic acid) (PLGA) nanoparticulate delivery system for
Indocyanine Green (ICG), to enhance the potential for ICG use in tumor imaging and therapy. Methods. For this purpose PLGA nanoparticles entrapping ICG were engineered by spontaneous emulsification solvent diffusion method. ICG entrapment in nanoparticles was determined and physicochemical characterization of nanoparticles was performed. The stability of ICG in nanoparticles formulation under various conditions was determined. The
intracellular uptake of ICG in nanoparticles by B16-F10 and C-33A
cancer cell lines was studied in