Authors: Italy) Capo Boi Conference on Neuroscience 1989 (Villasimius, P. F. Spano, G. Toffano, Giovanni Biggio
Hardbound. This volume focuses on new knowledge concerning the
pathophysiological correlates of irreversible ischemic brain damage. Central to this theme is the well established finding that glutamate is lethal to brain cells following
cerebral ischemia whilst, paradoxically, it is the most important neurotransmitter under normal physiological conditions. It has been shown that the neurotoxic effects of glutamate are due to an abusive stimulation of specific
glutamate receptors leading to autophagic cell death. By manipulation of these receptors with allosteric and isosteric inhibitors it has proved possible to limit ischemic brain damage. This and other important considerations such as