Author: Dinesh K. Haswani
Abstract Biodegradable Microspheres (MS) showing targeting ability, prolonged release, sustained action has opened a new field in drug delivery. The first biodegradable and biocompatible albumin MS were formulated in 1970's, earlier used for diagnostic purposes in detecting abnormalities of
reticuloendothelial system (RES) and estimation of the activation of macrophages, now their importance in drug delivery systems is well understood and documented. Albumin MS are easily metabolized and the factors influencing its metabolism are the size of particles, degree of
stabilization and the site of metabolism (Bernard et al.). Gentamicin is one of the aminoglycosides and an important group of…
