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Read book description Design and synthesis of foscarnet-peptide conjugates, halogenated bisphosphonates and
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Generic Zenate information



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Brand Name: Zenate
Generic Drug: multivitamin, prenatal

Active Ingredients: folic acid; multiple vitamins with iron and minerals, prenatal
Dose Form Description: tablet
Route Description: oral
Zenate Strength Description: Prenatal Multivitamins

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Solvay Pharmaceuticals Inc

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Design and synthesis of foscarnet-peptide conjugates, halogenated bisphosphonates and phosphonocarboxylates and biochemical sensing using film-bulk-acoustic-resonators: (Dissertation)
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Design and synthesis of foscarnet-peptide conjugates, halogenated bisphosphonates and phosphonocarboxylates and biochemical sensing using film-bulk-acoustic-resonators: (Dissertation)


Author: Mong Sano Marma
Manufacturer: ProQuest Information and Learning
Keywords: foscarnet
ISBN: B000GKZD38

Book description
Abstract A practical method for synthesis and isolation of previously elusive deprotected P-N linked foscarnet-amino acid conjugates was developed. The conjugates are good candidates for evaluation as foscarnet prodrugs as they release the active drug quantitatively under physiological conditions leaving only benign amino acids as by-products. A number of alkyl ester-protected thiophosphonoformate-peptide conjugates were synthesized via coupling between dimethyl-TPFACl and C-alkyl protected amino acids. An easily scalable, safe and cleaner method for synthesis of dimethyl-TPFACl was developed. The conjugates were treated with a series of dealkylating agents, such as t-BuNH2, NaOH, NaI, LiBr…


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