Cytomegalovirus retinitis and corneal keratitis are two clinically significant ocular viral infections, induced by cytomegalovirus and
herpes simplex virus type 1, respectively. Although ganciclovir is primarily indicated for treating
cytomegalovirus infections, the drug exhibits significant antiviral activity against all herpes viruses. However, factors such as low solubility and poor transcellular permeability, limit ganciclovir's utility in treating ocular herpes infections. Though several approaches have been employed to enhance ocular bioavailability of ganciclovir, it still remains the focus of drug delivery research. The overall objective of this dissertation project was to delineate…
