This past decade has led to many significant advances in the understanding of the function of
excitatory amino acids in synaptic transmission. The cloning of the ionotropic and metabotropic glutamate receptor families of receptor proteins has produced new strategies for the pharmacological modulation of glutamate transmission. The engineering of
transgenic animals with modified expression of receptor proteins has created new insights into the function, dysfunction and possible pathology causally related to glutamate receptors. Advances in the pharmacology of glutamate receptors has lead to clinical research addressing multiple
therapeutic applications of drugs that act on excitatory amino…
