In the last two decades it has become increasingly clear that the efficacy of antibiotics for the treatment of infectious diseases is in jeopardy due to the appearance of drug resistant strains of microorganisms. Understanding the mechanisms of
antimicrobial resistance is crucial for effective patient care in the clinic and essential for
developing strategies to enhance biodefense against intentionally disseminated pathogens. Fosfomycin, (1R, 2S)-expoxypropylphosphonic acid, is a potent, broad-spectrum antibiotic effective against both Gram-positive and Gram-negative microorganisms. A decade after its introduction, plasmid-mediated resistance to fosfomycin
was observed in the clinic.
